Req #: 1903179
Location: Seattle, Washington, United States
Job Category: Technical Development
Work Location: 400 Dexter Ave N. 98109
Employee Status: Full-time
Job Type: Regular
Job Description Template
Research Associate, Allogeneic Program, Product Sciences
Replacement for (if backfill):
In Current Budget?
Budgeted Start (if applicable):
Juno Therapeutics is a clinical-stage company developing novel cellular immunotherapies based on two distinct and complementary platforms – Chimeric Antigen Receptors (CARs) and T Cell Receptors (TCRs) technologies. Our goal is to revolutionize medicine by re-engaging the body’s immune system to treat cancer.
The Cell Therapy Product Sciences department is seeking a Research Associate to support the development of allogeneic CAR T cell products. The Product Sciences Team is responsible for developing and executing mechanism of action and characterization studies to support the development of gene-engineered T cell therapies. Successful candidates will have a strong foundation in human T cell biology and a proven track-record of implementation and optimization of a broad range of vitro cell-based and molecular assays using human immune and tumor cells. The primary focus of the T Cell Product Characterization Associate Scientist role will be to build CAR T cell product and process understanding.
Design and deploy in-depth characterization of gene-engineered T cells using flow cytometry, genome-wide expression analysis, metabolic profiling, and additional cutting edge analytical techniques.
Participate and lead cross-functional teams to support the development of gene-engineered T cell therapeutic platforms.
Identification and prioritization of novel analytical approaches for interrogating gene-engineered T cell function.
Develop and maintain relationships with external collaborators and service providers.
B.S. degree in immunology, or related field with 0-2 years of relevant experience.
Experience with human T cell biology and analytical tools for interrogating T cell phenotype and function.
Experience with multi-parameter flow cytometry and in vitro T cell functional assays.
Proven ability to work in a high paced team environment, meet deadlines, & prioritize work on multiple projects.
Excellent interpersonal, written and verbal communication skills and detail orientation
Experience with standard and next generation analytical platforms for the characterization of T cell phenotype, differentiation, and function.
Experience with data visualization software and/or coding-based data analysis (R or Python)
Understanding of cell signaling pathways involved in memory T cell differentiation.
Experience authoring regulatory documents, including IND and BLA filings.
Track record of successful internal and external scientific collaborations.
THINK BIG. BE BRAVE. DELIVER.
COMMITTED TO IMPROVING THE LIVES OF PATIENTS WORLDWIDE
At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
'At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients.'
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.